Mahatma Gandhi University

Institute for Intensive Research in Basic Sciences (IIRBS)

 

Institute for Intensive Research in Basic Sciences (IIRBS)
{Site Under Construction}

 
     
    
     
           
     
  Prof(Dr.) I. Ibnusaud
MSc. PhD (IIT Madras)
Director
E-mail : i.ibnusaud@gmail.com
Phone No : (91)481-2732992
           
Current position
:

Director
Institute for Intensive Research in Basic Sciences (IIRBS) - A centre under M.G.University instituted for the virtual enrichment of Teaching and Research.

Professor, School of Chemical Sciences M. G. University, Kottayam.

2009 (June-July)
:

Visiting Scientist ,
Department of Chemistry and Biochemistry,
University of Texas in Arlington, Texas, USA.

2006 (Oct-Jan)
:

Distinguished Invited Scientist,(BrainKorea-21)
Functional Materials Division,
Pusan National University,Busan, Korea.

1993 (July)
:

Lecturer
School of Chemical Science,
M.G University, Kottayam.

1991-1992
:

Fellow Scientist (CSIR)
Regional Research Laboratory, Trivandrum.

  Education

1986-1991 : Ph.D. (Synthetic Organic Chemistry)
Indian Institute of Technology, Madras
1988 : National Eligibility Examination - CSIR,JRF,March 1988
1985 : Common Examination for Research Admissions (CERA)(For IIT Admisions)
1983-1985 : M.Sc. Chemistry , N.E.H.U. (Central University) Shillong

  Unique distinctions
:

Scientific observer to the Indian team of 38th International Chemistry Olympiad held at Gyeongsan, Korea during July 2 nd -11 th , 2006.
Best paper award for the paper presented in ‘Chirality 2004' held at New York University, New York U.S.A.(2004).

   

Research contribution at Mahatma Gandhi University

At M.G.university (1993), Dr.Ibnusaud initiated research work in the synthesis of enantiopure compounds (epc synthesis) using chiral building blocks obtained from regional resources; an area different from his PhD work. Efficient methods have been developed for the isolation of (2 S ,3 S ) and (2 S ,3 R )-tetrahydro-3-hydroxy-5-oxo-2,3-furandicarboxylic (garcinia and hibiscus) acids in a kilogram scale and these molecules have been converted to chiral six carbon frame work related to chiral ?- buterolactones such as bis -lactones, pyrrolidines and furopyrans, otherwise difficult to synthesize. Thus for the first time, title acids have been employed as chirons and added to the existing select list of chiral molecules obtained from the chiral pool. This area of Research work is totally different for the research areas of the PhD or the PDF work. Prof.Ibnusaud and his group, developed his own organic chemistry utilizing naturally occurring chiral molecules obtained from locally available plant sources. For the first time among Universities in Kerala, he obtained 6 US and 12(+5) Indian patents from the research work exclusively done at M.G.university. All his research has been published in leading journals, such as J.Nat.prod., J.Phys.Chem.A. Eur.J.Org.Chem, Tet.Lett., and Tetrahedron . He has executed 7 major research projects and established a state of the art research facility (including first major instrument, NMR, procured for the University through IRHPA), which extend service to this region's research community.11 students obtained their PhD Degree under his supervision and four more are doing their Research work. In addition he has been guiding around 90 MSc and MPhil (together) students for their project work. He is the only person working in the area of organic synthesis (synthesis of natural products) among Universities in Kerala.

 
Research Projects Undertaken
   

1.

Synthesis of few Medicinally Important Chiral Molecules Derived from Renewable Resources DST, Govt. of India, Project No.SR/S1/OC-98/2012 dated 07.03.2013 (on going)

   

2.

Ex-chiral pool synthesis towards few molecules of Anticancer &Anti-tuberculosis Likeness. CSIR Project No. 02(0101)/12/EMR-II dated 31.10.2012 (on going)

   

3.

Asymmetric Transformations Employing (-Hydroxycitric acid) DST (Govt. of India) Project No.: SP/S1/G-07/95/PR (Completed).

   

4.

EPC Synthesis Using Naturally Occurring g -Butyrolactones: First Synthesis of Funebrine, Funebral and PLA 2 Inhibitors Cinatrin C 2 , C 3 ; Short and Practical Synthesis of flavor Components of aged Alcoholic Beverages DST, Govt. of India Project No.: SR/S1/OC-47/2003, (completed).

   

5.

A chiral pool protocol towards the synthesis of molecules for chiral discrimination. DST, Govt. of India Project No.: SR/S1/OC-54/2007(completed)

   

6.

DST Inter University NMR Facility (IRHPA Scheme) DST, Govt. of India Project No.: IR/S1/CU/01/2007(ongoing)

   

7.

University Centre for guiding Innovative research and Development and protecting Intellectual Property Rights (UCIPR) President's Mission Project, Govt. of Kerala (2008).

   

8.

An Innovative MS Programme 2009.

   

9.

Interdisciplinary Integrated PhD Programme 2012

  Publications and Patents
   

1.

Palladium-Catalyzed a-Arylation Reactions in Total Synthesis; Sudheesh T. Sivanandan, Ashna Shaji, Ibrahim Ibnusaud , Carin C. C. Johansson Seechurn and Thomas J. Colacot, Eur. J. Org. Chem . 2015, 38–49

   

2.

Synthesis of enantiopure furo[2,3-b]pyrroles, Nair,D.S.;Ibnusaud,I.; Tetrahedron Letters, 2014, 55, 5822 - 5824

   

3.

Enantiomerically pure compounds related to chiral hydroxy acids derived from renewable resources: RSC Adv. , 2012 , 2, 9257-9285., Simimole Haleema, PaleapadamVavan Sasi, Ibrahim Ibnusaud , Prasad L. Polavarapu and Henri B. Kagan

   

4.

Chiroptical spectroscopy of of Natural products: Avoiding the Aggregation of Chiral Carboxylic Acids , J. Nat. Prod. , 2012 , 75 , 1441–1450; Prasad L. Polavarapu, Emily Donahue, Ganesh Shanmugam, Ibrahim Ibnusaud , Divya S. Nair, Chithra Gopinath and Deenamma Habel

   

5.

Polavarappu, Prasad; Donahue, Emily; Shanmugam,Ganesh; Scalmani, Giovanni; Hawkins, Edward; Rizzo, Carnelo; Ibrahim Ibnusaud ; Thomas, Grace; Habel, Deenamma; Sebastian, Dellamol; A single chiroptical spectroscopic method may not be able to establish the absolute configuration of diastereomers: Dimethyl esters of Hibiscus and Garcinia Acids. J.Phys.Chem.A 2011, 115, 5665–5673

   

6.

Prasad L. Polavarapu , Giovanni Scalmani , Edward K. Hawkins, Carnelo Rizzo, NehaJeirath, Ibrahim Ibnusaud , DeenammaHabel, DivyaSadasivan Nair and SimimoleHaleema; Importance of solvation in understanding the chiroptical spectra of natural products in solution phase: Garcinia acid dimethyl ester, J. Nat. Prod. , (ACS ), 2011 , 74 ,321-328.

   

7.

Susan Varghese, Salini Thomas, SimimoleHaleema, Tom Thomas Puthiaparambil and Ibrahim Ibnusaud ; Synthesis of enantiopure concave(+)-avenaciolide and (-)-canadensolide skeletons, Tetrahedron Letters, 2007, 48 , 8209-8212.

   

8.

Chithra g opinath, Salini Thomas, MangalamS.Nairand I. Ibnusaud; Analogues of Quararibea Metabolite chiral enolic -?-lactones from (2 S , 3 S ) and (2 S , 3 R )-tetrahydro-3-hydroxy-5-oxo-2, 3-furandicarboxylic acid. Tetrahedron Letters,2006, 47,7957-7960

   

9.

Ibnusaud, I. and Grace Thomas; Biologically interesting chiral 3, 4-disubstituted pyrrolidines from optically active hydroxycitric acid lactones. Tetrahedron Letters, 2003 , 4, 1247-1249 CAN 139:245844

   

10.

 

Ibnusaud, I.; Thomas,T.P.; Rani,R.N.; Sasi, P. V.; Beena T.;Hisham, A. K. Chiral ?-Butyrolactones related to optically active 2-hydroxycitric acids. Tetrahedron 2002 ,58,4887-4892

   

11.

I.Ibnusaud, E.J.P. Malar and N. Sundram, Synthesis and Diels-Alder Reaction of Stable Aryl free1, 3-Diazabutadiene.Tetrahedron Letters , 1990 , 31, 7357 CAN 114:164138

   

12.

S.N. Muzumbar, I.Ibnusaud and M.P. Mahajan, Diels-Alder Cyclo Addition Reactions of 1,3-Diazabytadiene with Ketenes. Tetrahedron Letters , 1986 , 27, 5875. CAN 106:213891

   

13.

Ibnusaud, I., Gopinath, C., Thomas, B . Chiral Derivatives of Hibiscus acid bearing lactone ring moiety, process for preparing the same and a convenient method for the large scale isolation of Hibiscus acid. U.S. Patent No . 6,703,515 , (9 th March 2004 ) CAN 138:369115.

   

14.

Ibnusaud, I., Nair, R. R.; Philip, T; Thomas, S. A convenient method for large-scale isolation of hibiscus acid. U. S. Patent no .6,127, 553 ( 3 rd October 2000 ) CAN 133:271625.

   

15.

Ibnusaud, I.; Thomas,G.; Sasi, P.V.a) A Novel Chiral derivatives of Garcinia acid bearing lactone ring moiety and process for preparing the same. U. S. patent no 6,489,492B2 ( 3 rd December, 2002 ) CAN 137:247883.

   

16.

Ibnusaud, I., Nair, R. R.Novel Acyclic chiral derivatives of hibiscus acid and the process for preparing the same. U. S. patent no6,489,493B2 (3 rd December, 2002 ) CAN 136:325781.

   

17.

Ibnusaud, I., Thomas P.T. Acyclic chiral compound from Garcinia acid and process for preparing the same. U. S. Patent no . 6, 706, 899 (16 th March 2004 ) CAN 136:295022.

   

18.

Ibnusaud, I., Thomas T. P., Thomas, B. A convenient method for the large scale isolation of garcinia acid. U. S. Patent no. 6, 147, 228 (14 th November 2000 ) CAN 133:335435.

   

19.

Ibnusaud, I., Nair, R. R.; Philip, T; Thomas, S. A convenient method for large-scale isolation of hibiscus acid. Indian patent no : 189745 (23 rd January 2004 ).

   

20.

Ibnusaud, I., Thomas T. P. Thomas, B. A convenient method for large-scale isolation of garcinia acid. Indian patent no. 190387 (27 th January 2004 ).

   

21.

Ibnusaud, I., Thomas P.T. Novel Acyclic Chiral compounds from Garcinia acid and process for preparing the same. Indian patent no . 192500

   

22.

Ibnusaud, I., Nair, R. R. Novel acyclic chiral derivatives of hibiscus acid and the process for preparing the same. Indian patent no. 192949

   

23.

Ibnusaud, I., Gopinath, C.; Thomas, B. Novel Chiral Derivatives of Hibiscus acid bearing lactone ring moiety and process for preparing the same.Indian patent no: 192481 .

   

24.

Ibnusaud, I.; Thomas, G.; Sasi, P.V. Novel Chiral derivatives of Garciniaacid and a process for preparing the same. Indian patent no. 192471 .

   

25.

Ibnusaud, I., Thomas P.T. Novel Acyclic Chiral compound ofGarcinia acid bearing lactone ring moiety and process for preparing the same. Indian patent no. 1427/Del/03,2003

   

26.

Ibnusaud, I., Nair, R. R. A process of preparing acyclic chiral triesters; Indian patent no. 1452/Del/04,2004

   

27.

Ibnusaud, I., Gopinath, C.;Thomas, B. A Process of Preparing Novel Chiral compound of Hibiscus acid bearing lactone ring moiety, Indian patent no. 1425/Del/03, 2003

   

28.

 

Ibnusaud, I.; Thomas,G.; Sasi, P.V. A process of preparing novel chiral derivatives of Garcinia acid bearing Lactone Moiety Indian patent no. 1426/Del/03, 2003

   

29.

Ibrahim Ibnusaud and Sarath Muralidharan Pillai. Enatiopure total synthesis of indolizinoindole alkaloid (+)harmicine and (-) harmicine from (2S,3R)-Tetrahydro-3-hydroxy-5-oxo -2,3-furandicarboxylic acid (Hibiscus acid ) and (2S,3S)-Tetrahydro-3-hydroxy-5-oxo -2,3-furandicarboxylic acid(Garcinia acid ) Indian Patent application filed 2015.

   

30.

 

Synthesis of ( R )-( + )- Crispine A and ( S )-( - )- Crispine A from(2 S ,3 R )- and (2 S ,3 S )-Tetrahydro-3-hydroxy-5-oxo-2,3-furandicarboxylic acids, Divya Sadasivan Nair, Deenamma Habel and Ibrahim Ibnusaud, Indian Patent application filed 2015.

       
  Paper Presentation / Lecture given in National / International conferences (2004-2014)
   

1.

11 B NMR Spectroscopy Based Mechanistic Insight into Reduction Reactions of Hydroxyacid esters” BORON AMERICAS XIV (BORAM), Rutgers, The State University of New Joursey, NJ , US to be held on June 15 th -19 th 2014. Chaired a session and presented a paper.

   

2.

“Synthesis of enantiopure 3-substituted, 3, 4-disubstituted pyrrolidinediones and related isoquinoline alkaloid”; Divya S. Nair, Deenamma Habel, Grace Thomas, and Ibrahim Ibnusaud, ACS Meeting March 16-20, 2014 , Dallas, Texas

   

3.

Ex-Chiral pool synthesis of Chiral 4-(2-Hydroxyethyl) pyrrolidine-3-ol: a potent anti-tuberculosis agent, Ibrahim Ibnusaud,24 th International symposium on chiral Discrimination ISCD24,USA , June 10-13, 2012

   

4.

Semi synthetic production of potential enantiomerically pure molecules employing Boranes and Borohydride Reagents,I.Ibnusaud*,H.Simimole, Divya SNair and K.C SachinRaj , Boron Americas XIII , Purdue University USA , June 3-9 2012

   

5.

Ex-Chiral pool synthesis towards butyrolactone based molecules of agro–pharmaceuticals and functional interests: A green approch, Sasi P.V, Simimole H and I.Ibnusaud, 11 th National Convention of Chemistry Teachers (NCCT-2011) & National Seminar on Emerging Trends in Green Chemistry, Dept. of Chemistry, A.N College, Patna , India, Oct.15-17, 2011

   

6.

Ex-Chiral pool synthesis of Chiral 4-(2-Hydroxyethyl) pyrrolidine-3-ol: a potent anti-tuberculosis agent, Arshad Sayed M.V , Grace Thomas and I.Ibnusaud, Medicinal Chemistry Conference on Anti-Infective Drug Discovery and Development,Dept. of Chemistry, IIT, Madras , Oct.28-29, 2011.

   

7.

Semisynthetic route towards therapeutically active a-methylene-?-butyrolactones, Sudheesh T.S and I.Ibnusaud, Medicinal Chemistry Conference on Anti-Infective Drug Discovery and Development, Dept. of Chemistry, IIT, Madras , Oct.28-29, 2011.

   

8.

A modified Antibiotic Based on (2S,3S) –Tetrahydro-3- Hydroxy-5-Oxo-2,3-Furandicarboxylic Acid and 6-Aminopencillianic Acid, Surya.K and I.Ibnusaud, Medicinal Chemistry Conference on Anti-Infective Drug Discovery and Development, Dept. of Chemistry, IIT, Madras , Oct.28-29, 2011.

   

9.

Inaugural Lecture on Asymmetric Synthesis, Navathy Celebration and International Year of Chemistry 2011, I.Ibnusaud, S.B College, Changanacherry , Kottayam, Kerala, Oct.14, 2011.

   

10.

A novel class of chiral phosphine ligand based on(2S,3S) – Tetrahydro-3-hydroxy-5-oxo-2,3,furan dicarboxylic acid , I.Ibnusaud, S. Anumol and Ashna Shaji (ISCD – 2011) University of Liverpool, Liverpool, UK . Presented on 10 th July to 13 th July 2011).

   

11.

Renewable resources for the syntheses of enantiomerically pure molecules related to chiral 2-Hydroxy Citric Acids 22 nd International symposium on Chirality (ISCD – 2010) Sapporo, Japan, July 12-15 2010

   

12.

Invited lecture in summer workshop on” Chiral Molecular Determination and Analysis” June 7-9, 2010 Vanderbilt University , Nashville, USA.

   

13.

“Tropical Plants and Chirality”; National Conference on Emerging Advances in Chemistry (NCCT 2009) organized by Gayatri Vidya Parishad, Visakhapatnam and Indian Association Of Chemistry Teachers held at Visakhapatnam during Nov.13-15,2009.

   

14.

Enantiomerically Pure compound Synthesis Using Chiral ?-butyrolactones-A Green approach 21 st International symposium on Chirality (ISCD – 2009) Colorado,USA.

   

15.

Chiral pool protocol towards this synthesis of molecules for Chiral discrimination . 20 th International symposium on Chirality (ISCD – 2008) Geneva Switzerland during July 6th – 9 th , 2008.

   

16.

Out sourcing chiral ?-butyrolactones for the synthesis of (+) phaseolinic acid, (+) Nephromopsiric acid,ß-hydroxy paraconic acid, (4R,5R)-4,5-dimethyldihydro-2(3H)-furanone. The 19 th International Symposium on Chirality (ISCD-19). San Diego, CA, USA during 8 th -11 th July 2007

   

17.

Chiral pool approach towards the synthesis of chiral butyrolactone based molecules .Gyeongsang National University, Jinju, Korea, 29 th Nov. 2006 .

   

18.

Synthesis of Natural products a green approach, Department of chemistry, Pusan national University, Pusan, Korea. Dec. 2006

   

19.

IPR and R&D Tuning Research for Development. International Seminar on India and the New Global Intellectual Property Rights (IPR) Regime held at School of International Relations and Politics, M.G.University, Kottaym During 2-4 th August 2006 .

   

20.

Access to Analogues of (+)-Avenaciolide and (+)- Canadensolide and Quararebia Metabolite chiral enolic - g - butyrolactone: The 18 th International Symposium on Chirality (ISCD-18).Busan, Korea during 25 th -28 th June 2006

   

21.

17th International symposium in Chirality (chirality 2005).Parma, Italy during September 11-14 , 2005.

   

22.

17th International symposium in Chirality (chirality 2005).Parma, Italy during September 11-14 , 2005.

   

23.

Synthesis of Enantiomerically pure ?-butyrolactone based molecules-A Green Approach. 16 th international symposium in chirality (Chirality 2004), New York University, New York during July11-14, 2004

   

24.

 

3-Substituted Pyrrolidinedione Based Chiral Molecular Clefts; 8 th National Symposium in chemistry (CRSI) held at IIT Bombay during Feb.3-5 , 2006

   

25.

Tropical Plants and Chirality; 2 nd International conference on Organic synthesis and process chemistry( OSPC-2005) held at IICT, Hyderabad

   

26.

Isocitric and analogue of Avenaciolide from (2S, 3S) - Tetrahydro-3-Hydroxy-5-Oxo-2, 3-Furandicarboxylic Acid; 7 th National Symposium in chemistry(CRSI) held at IACS Kolkata during Feb.4-6 2005